GMP-compliant, automated, closed-system bioprocessing in microgravity
OSPRI brings the tools of a modern cell-manufacturing suite into orbit as one integrated platform, from cryovial thaw to culture, analysis and sealed sample return.
Linear scale-up of shear-sensitive cell products
The OSPRI reactor uses validated terrestrial vertical-wheel technology. The wheel impeller keeps a consistent hydrodynamic environment across scales, giving consistent cell quality and yield and an unparalleled 3D culture environment.
Independently controlled pumps handle media exchange, sampling and aeration. Gas and bubble control was developed with experts in multi-phase flow in microgravity, and is one of the platform's most novel features.
The operating system gives real-time, remote monitoring and control of the culture environment, with machine-learning tools for O₂ and CO₂ control, which is essential for biomanufacturing scale-up.
- Wheel speed
- 1–150 rpm
- Reactors per controller
- Up to 8 simultaneous
- pH
- 5.0–8.5
- Dissolved O₂
- 0–100 %
- pCO₂
- 10–250 hPa
- Optical density
- Inline spectrometry
Everything a culture needs, from launch to return
Scalable Bioreactor
Vertical-wheel vessels with automated media delivery, removal and recirculation, gas exchange, and non-invasive optical sensing through the vessel wall.
Perfusable Chambers
Alternate vessel configurations support immobilized/adherent cultures, aeration and continuous perfusion.
Cell Thawing
Industry-leading, GMP-ready automated thawing of cryovials with customizable thaw profiles that remove subjectivity.
Cell Analysis
Cassette-based, rapid and reproducible cell counts and viability, avoiding variability and human error.
System Sealing
Sealing technology for closed, sterile transfer of samples and products, with a path to robotic operation.
Cell Imaging
Automated imaging of cultures for morphology and growth tracking over the mission.
Robotic Manipulation
Designed to accommodate robotic operation, to take over crew-tended steps and support uncrewed commercial platforms.
Real-time pH, oxygen and CO₂ without touching the culture
Sensors work on the principle of fluorescence quenching, giving a continuous, non-contact, non-destructive measure of the culture environment.
Closed system — from frozen cryovial to sealed sample
Industry-leading sterile technologies for cell and gene therapy work at ultra-low temperatures, so cells launch frozen, are thawed and cultured on orbit, and return without opening the system.
Built for translational, commercial-grade results
- Scalability
- Designed for greater scale-up
- Efficiency
- Higher yields and faster cycles
- Accuracy
- Validated commercial platforms
- Cost
- Single-use technology, lower CapEx
- Automation
- Reproducible, robotic-compatible
- Analytics
- Standardized, translational data
The same platform on the ground and in orbit
OSPRI shares its vessels and commercial ground unit with systems the biomanufacturers already use. Processes move both ways: developed on Earth, run in orbit, and brought back to terrestrial production.
Earth ↔ orbit translation
Ground testing and flight runs on matched hardware.
Validation on ISS
First validation mission flies in 2027.
Reproducible performance
Automated, sensor-driven processes in place of manual steps.
Multiple platforms
Designed for the ISS, free-flyers and commercial LEO destinations.